Patterning the Mechanical Properties of Hydrogen Silsesquioxane (HSQ) Films Using Electron Beam Irradiation for Application in Mechano Cell Guidance

Lanniel, Mathieu
Lu, Bingrui
Chen, Yifang
Allen, Stephanie
Buttery, Lee
Williams, Phil
Huq, Ejaz
Alexander, Morgan

¹Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
²Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, UK.

Journal of Pharmacy and Pharmacology 62(10):p 1346-1347, October 2010.

Abstract

- The effects of electron beam dose on the topography and the mechanical properties of Hydrogen Silsesquioxane (HSQ) are characterised using atomic force microscopy (AFM). The changes of the HSQ stiffness and roughness of a “development step” used to remove uncured material employing trimethylamine (TMA) are investigated. The attachment of human mesenchymal stem cells (hMSC) cultured on HSQ coated with plasma polymerised allylamine is demonstrated.