Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gαq
- Takano, Takahiro
- Franchini, Luca
- Wagner, Larry E. II
- Cooley, Michelle
- Groblewski, Guy E.
- Orlandi, Cesare
- Yule, David I.
1Department of Pharmacology and Physiology University of Rochester Rochester New York USA
2Department of Nutritional Sciences University of Wisconsin Madison Wisconsin USA
Corresponding authors C. Orlandi and D. I. Yule: Department of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA. Email: [email protected] and [email protected]
Takahiro Takano completed his PhD in cell biology at New York Medical College and is currently an assistant professor in the Department of Pharmacology and Physiology at the University of Rochester Medical Center. Since 2019 his research has focused on establishing methods to directly measure Ca2+ dynamics in exocrine glands of live animals under physiological conditions utilizing multiphoton microscopy and genetically encoded calcium probes expressed in intact tissue.
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Luca Franchini has completed his PhD in pharmacological, experimental and clinical sciences at the University of Milan in 2021, focusing on hippocampal synaptic plasticity and NMDA receptor pharmacology. Since then he has been a postdoctoral fellow at the University of Rochester in Cesare Orlandi's laboratory, investigating orphan G protein‐coupled receptor signalling and uncovering their endogenous ligands.
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Received March 25, 2025
Accepted June 06, 2025
