Correlation and Agreement of Anterior Chamber Biometric Parameters and Sulcusto-Sulcus Diameter in Chinese Patients With High Myopia and Varying Axial Lengths

Huang, Yuyan MD
Xu, Huiling
Yang, Xiaoling
Huang, Hehe
Zhi, Zhina MD, PhD
Chen, Si MD, PhD

From National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, People's Republic of China; and State Key Laboratory of Ophthalmology, Optometry, and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, People's Republic of China.

Equal contribution: YH and HX contributed equally to the work and should be considered equal first authors.

Funding: This work was funded by a grant from the National Natural Science Foundation of China (No. 82271121), and a grant from the Department of Science and Technology of Wenzhou City (No. Y20240346).

Disclosure: The authors have disclosed no potential conflicts of interest, financial or otherwise.

Address correspondence to Zhina Zhi, MD, PhD ([email protected]) and Si Chen, MD, PhD ([email protected]), School of Optometry and Ophthalmology, and Eye Hospital, Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, Zhejiang, 325003, People's Republic of China.

Received November 02, 2024

Accepted June 12, 2025

Journal of Refractive Surgery 41(8):p e805-e813, August 01, 2025. | DOI: 10.3928/1081597X-20250612-01

Purpose

To evaluate the relationship between anterior chamber biometric parameters (angle-to-angle diameter [ATA] and anterior chamber width [ACW]) and the sulcus-to-sulcus diameter (STS) in myopic patients with varying axial length (AL).

Methods

A 50-MHz ultrasound biomicroscopy (UBM) device measured STS at the 0° and 90° meridians in the right eyes of 77 Chinese patients with high myopia and an anterior chamber depth greater than 2.80 mm. Swept-source optical coherence tomography device (CASIA2; Tomey) measured ATA and ACW at the 0°, 45°, 90°, and 135° meridians, whereas corneal topography measured the horizontal white-to-white diameter (WTW-0°).

Results

Vertical STS, ATA, and ACW measurements were significantly longer than their horizontal counterparts (P < .001). Differences in STS and ACW between vertical and horizontal meridians were comparable (P = .503), whereas ATA differences was more pronounced than that of STS (P = .032). Both STS-0° and STS-90° were significantly greater than WTW-0°, ATA, and ACW at their respective meridians (P ≤ .016), except for STS-0° versus ACW-0° (P = .127). Correlations between STS-0°/STS-90° and WTW-0° were weaker than those with ACW or ATA. STS-0° exhibited the strongest correlation with ACW-0°, whereas STS-90° correlated best with ACW-45°. For patients with AL shorter than 28.5 mm, no significant differences existed between STS-0° and WTW-0°/ATA-0°/ACW-0°. In contrast, for those with AL greater than 28.5 mm, only ACW-0° was comparable to STS-0°. At the vertical meridian, only ACW had no significant differences compared to STS for patients with different ranges of AL.

Conclusions

In Chinese patients who are potential candidates for Implantable Collamer Lens implantation, ACW shows better concordance with STS than ATA and WTW-0°. The reliability of WTW-0° for estimating STS decreases with increased AL, making ACW more suitable for STS estimation in patients with AL greater than 28.5 mm, especially at non-horizontal meridians.