Efficacy of Prilocaine-Lidocaine Cream in Treatment of Premature Ejaculation

Berkovitch, Matitiahu
Keresteci, Ara G.
Koren, Gideon

From the Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children and Division of Urology, Wellesley Hospital and the University of Toronto, Toronto, Ontario, Canada.
Accepted for publication March 24, 1995.

Journal of Urology 154(4):p 1360-1361, October 1995.

Purpose

We evaluated the efficacy of a new lidocaine-prilocaine cream in preventing premature ejaculation.

Materials and Methods

An open pilot, unblinded study was done using lidocaine-prilocaine cream in 11 healthy, married men with premature ejaculation without organic or erectile problems. The patients were instructed to apply 2.5 gm. of the cream 30 minutes before sexual contact and to cover the penis with a condom. Patients were asked to grade the effect of the cream on ejaculation after each application.

Results

There was a significant improvement in premature ejaculation statistically and clinically. Five patients graded the result as excellent compared to baseline, 4 graded it as better and 2 claimed to have no change compared to ejaculation before use of the cream. No adverse effects were noted.

Conclusions

These promising results should prompt a large double-blind placebo-controlled trial. If confirmed, this therapy may be a breakthrough in the treatment of the most common form of male sexual dysfunction.