Failure of amniotic-fluid-cell growth

is it related to fetal aneuploidy?

Persutte, Wayne H
Lenke, Roger R.

Department of Obstetrics and Gynaecology, University of Colorado Health Sciences Center, Campus Box E-197, 4200 East 9th Avenue, Denver, CO 80262, USA (W H Persutte, BS; R R Lenke, MD).
Correspondence: Mr Wayne H Persutte.

The Lancet 345(8942):p 96-97, January 14, 1995.

We investigated outcome in patients whose amniotic-fluid-cell samples showed unexplained growth failure in culture. 32 of 7872 amniocentesis samples were classified as unexplained growth failures. 10 women did not have repeat cytogenetic testing, but among their pregnancies there were 4 abnormal outcomes (1 fetal bladder-outlet obstruction, 2 stillbirths, and 1 acardiac twin). Of the 22 patients who had repeat karyotypic analysis, 18 had normal fetal karyotypes. However, 4 fetuses were aneuploid (2 trisomy 21, 1 trisomy 13, and 1 Pallister-Killian syndrome).