Cell-cycle control and its watchman

Jacks, Tyler
Weinberg, Robert A.

Tyler Jacks is at the MIT Center for Cancer Research, Department of Biology, MIT, and the Howard Hughes Medical Institute. Robert A. Weinberg is in the Department of Biology, MIT, and the Whitehead Institute, Cambridge, Massachusetts 02139, USA.

Nature 381(6584):p 643-644, June 20, 1996.

The mammalian cell-cycle is controlled by systems that monitor the cell's health and act through the tumour-suppressor p53 and its effector, p21. Therapeutic intervention can restore order to tumour cells lacking p53.