1Division of Molecular Immunology,
2Division of Allergy and Immunology,
3Division of Developmental Biology, and,
4Division of Immunobiology, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
5Division of Infectious Diseases & Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA
6Department of Occupational and Environmental Health, and,
7Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52241, USA
8Veteran’s Affairs Medical Center, Iowa City, Iowa 52247, USA
Correspondence and requests for materials should be addressed to C.L.K. ([email protected]).
Received 19 Spetember 2008; accepted 14 October 2008
Published online 7 December 2008
Acknowledgements We thank S. Vogel for re-purified LPS; E. Kurt-Jones and R. Finberg for HEK293 cells expressing TLR4 complex proteins, N. J. Gay for discussions, and L. Flick and J. Bohnert for technical assistance. This work was funded by grants from the Sandler Foundation for Asthma Research (C.L.K.), the National Institute of Allergy and Infectious Diseases (C.L.K., J.P.W.), and the Veteran’s Administration (T.L.G.).
