Prime-time looping

Dixon, Nicholas E.

¹Nicholas E. Dixon is at the School of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia. e-mail: [email protected]

Published online 16 December 2009

Nature 462(7275):p 854-855, December 17, 2009. | DOI: 10.1038/462854a

When the replication machinery copies DNA, it must unwind the double helix in one direction while synthesis of one of the strands proceeds in the other. Making transient DNA loops may solve this directional dilemma.