TET2-Driver andNLRC4-Passenger Variants in Adult-Onset Autoinflammation

  • De Langhe, Ellen M.D., Ph.D.
  • Van Loo, Sien M.Sc.
  • Malengier-Devlies, Bert Ph.D.
  • Metzemaekers, Mieke Ph.D.
  • Staels, Frederik M.D., Ph.D.
  • Vandenhaute, Jessica Ph.D.
  • Berghen, Nathalie M.D., Ph.D.
  • Sciot, Raf M.D., Ph.D.
  • Corveleyn, Anniek Ph.D.
  • Tšuiko, Olga Ph.D.
  • Gouwy, Mieke Ph.D.
  • Lenaerts, Jan M.D.
  • Verschueren, Patrick M.D., Ph.D.
  • Wouters, Carine H. M.D., Ph.D.
  • Proost, Paul Ph.D.
  • Matthys, Patrick Ph.D.
  • Legius, Eric M.D., Ph.D.
  • Schrijvers, Rik M.D., Ph.D.

  • 1University Hospitals Leuven, Leuven, Belgium

    2KU Leuven, Leuven, Belgium

Ms. Van Loo and Drs. Malengier-Devlies, Metzemaekers, Staels, and Vandenhaute contributed equally to this letter.

Supported by grants from Fonds Wetenschappelijk Onderzoek-Vlaanderen (FWO, ) (G0A3218N and G080818N, to Drs. Wouters, Proost, and Matthys), C1 grants from KU Leuven, (C16/17/010, to Drs. Wouters, Proost, and Matthys; C12/16/024, to Dr. Schrijvers), a “For Women in Science” Ph.D. fellowship from L'Oréal, UNESCO, and FWO, (to Dr. Metzemaekers), a Ph.D. fellowship for basic research from FWO, (11B5520N, to Dr. Staels), a Ph.D. fellowship for strategic basic research from FWO, (1S10618N, to Dr. Vandenhaute), and an FWO, senior clinical investigator fellowship (1805518N, to Dr. Schrijvers).

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

New England Journal of Medicine 388(17):p 1626-1629, April 27, 2023. | DOI: 10.1056/NEJMc2212928

Genetic Events in Adult-Onset Inflammatory Disease

The case of a patient with adult-onset inflammatory disease is reported. Two somatic genetic events accounted for the disease and its onset in adulthood.

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