Retinoblastoma Origins and Destinations

Cobrinik, David M.D., Ph.D.

From the Vision Center, Department of Surgery, and Saban Research Institute, Children's Hospital Los Angeles, and the Departments of Ophthalmology and Biochemistry and Molecular Medicine, Roski Eye Institute, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California — both in Los Angeles.

Dr. Cobrinik can be contacted at [email protected] or at Children's Hospital Los Angeles, 4650 Sunset Blvd., MS #163, Los Angeles, CA 90027.

Disclosure forms provided by the author are available with the full text of this article at NEJM.org.

New England Journal of Medicine 390(15):p 1408-1419, April 18, 2024. | DOI: 10.1056/NEJMra1803083

Retinoblastoma

The study of retinoblastoma has led to fundamental insights into carcinogenesis, cell-cycle regulation, the genetic basis of cancer, and tumor-suppressor genes, as well as to advances in therapy.