Discovery of a new pyrimidine synthesis inhibitor eradicating glioblastoma-initiating cells

Echizenya, Smile
Ishii, Yukiko
Kitazawa, Satoshi
Tanaka, Tadashi
Matsuda, Shun
Watanabe, Eriko
Umekawa, Masao
Terasaka, Shunsuke
Houkin, Kiyohiro
Hatta, Tomohisa
Natsume, Tohru
Maeda, Yoshimasa
Watanabe, Shin-Ichi
Hagiwara, Shinji
Kondo, Toru

Division of Stem Cell Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
Pharmaceutical & Healthcare Research Laboratories, R&D Management Headquarters, Fujifilm Corporation, Kaisei-machi, Kanagawa, Japan
Safety Evaluation Center, Ecology & Quality Management Division, CSR Division, Fujifilm Corporation, Minamiashigara, Kanagawa, Japan
Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Koto-ku, Tokyo, Japan

Corresponding Author: Toru Kondo, Ph.D., Division of Stem Cell Biology, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, Hokkaido 60-0815, Japan ([email protected]).

These authors equally contributed to this research.

Neuro-Oncology 22(2):p 229-239, February 2020. | DOI: 10.1093/neuonc/noz170