Inhibition of PERK-mediated unfolded protein response acts as a switch for reversal of residual senescence and as senolytic therapy in glioblastoma

Ketkar, Madhura
Desai, Sanket
Rana, Pranav
Thorat, Rahul
Epari, Sridhar
Dutt, Amit
Dutt, Shilpee

Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India
Shilpee Dutt Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410210, India
Integrated Genomics Laboratory, Advanced Centre for Treatment Research Education in Cancer (ACTREC), Navi Mumbai, 410210India
Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India
Shilpee Dutt Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410210, India
Laboratory Animal Facility, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar, Navi Mumbai 410210, India
Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410210, India
Integrated Genomics Laboratory, Advanced Centre for Treatment Research Education in Cancer (ACTREC), Navi Mumbai, 410210India
Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India
Integrated Cancer Genomics Laboratory, Department of Genetics, University of Delhi South Campus, Benito Juarez Marg, New Delhi 110021, India
Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India
Shilpee Dutt Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi, India
Shilpee Dutt Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410210, India

Corresponding Author: Shilpee Dutt, PhD, School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India ([email protected]).

Revised September 03, 2024

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Neuro-Oncology 26(11):p 2027-2043, November 2024. | DOI: 10.1093/neuonc/noae134