Myopathy with Elevated Aldolase and Normal CK: Differential Diagnosis

Rubin, Michael MD

Professor of Clinical Neurology, Weill Cornell Medical College

Neurology Alert 43(6):p 44-45, February 2024.

SYNOPSIS: Elevated serum creatine kinase (CK) is considered the hallmark of myopathy, yet some patients with biopsy-proven myopathy have normal CK with elevated aldolase, a less-specific marker of muscle disease. Most of those cases ultimately prove to be dermatomyositis.

SOURCE: Soontrapa P, Shahar S, Eauchai L, et al. Disease spectrum of myopathies with elevated aldolase and normal creatine kinase. Eur J Neurol 2024;31:e16117.