Exploring the nature of miscellaneous blood and bone marrow disorders

This article on miscellaneous disorders of the blood and bone marrow explores the pathophysiology of hereditary haemochromatosis, antiphospholipid syndrome, and the lymphoma (Hodgkin's and Non-Hodgkin's) and multiple myeloma blood cancers. Infection with human T cell lymphotrophic-1 virus is also explained, as is its role in initiating aggressive adult T cell leukaemia and various inflammatory disorders.

This article has been double-blind peer reviewed

In this article…

• Features of hereditary haemochromatosis

• The pathology of antiphospholipid syndrome

• Characteristics of Hodgkin's and non-Hodgkin's lymphomas and multiple myeloma

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Key points

Hereditary haemochromatosis is a recessive genetic disorder causing iron overload

Antiphospholipid syndrome is an autoimmune disease that increases thrombosis risk

Human T cell lymphotropic virus is associated with inflammatory disorders and can cause aggressive adult T cell leukaemia

Lymphomas occur when malignant lymphocytes proliferate in the lymph nodes/spleen, resulting in palpable masses

Multiple myeloma is a bone marrow malignancy that leads to an excess of malignant antibody-secreting plasma cells