Delineating the "galectin signature" of the tumor microenvironment

Compagno, Daniel
Laderach, Diego J.
Gentilini, Lucas
Jaworski, Felipe M.
Rabinovich, Gabriel A.

¹Laboratorio de Glicómica Estructural y Funcional; IQUIBICEN-CONICET; Departamento de Química Biológica; Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires; Buenos Aires, Argentina
²Laboratorio de Inmunopatología; Instituto de Biología y Medicina Experimental (IBYME-CONICET); Buenos Aires, Argentina

^*Correspondence to: Daniel Compagno, Email: [email protected] and Diego J. Laderach, Email: [email protected] and Gabriel A. Rabinovich, Email: [email protected]

OncoImmunology 2(4):p e23565, April 1, 2013.

Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated ‘galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease.