Multiple hamartoma syndrome presenting with oral lesions

Porter, Stephen MD, PhD, FDSRCS, FDS
Cawson, Roderick MD, FDSRCPS, FDSRCS,
Scully, Crispian MD, PhD, MDS, FDSRCP
Eveson, John PhD, FDSRCPS, FDSRCS

EASTMAN DENTAL INSTITUTE AND HOSPITAL FOR ORAL HEALTH CARE SCIENCES, LONDON AND BRISTOL DENTAL SCHOOL AND HOSPITAL
^aDepartment of Oral Medicine, Eastman Dental Institute and Hospital for Oral Health Care Sciences, London.
^bDepartment of Dental Science, Bristol Dental School and Hospital, Bristol.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodontics 82(3):p 295-301, September 1996.

Multiple hamartoma syndrome (Cowden's syndrome), a rare genodermatosis with predominant mucocutaneous features, particularly hamartomas, and Cowden/Lhermitte-Duclos disease, the combination of multiple hamartomas with cerebellar hypertrophy, typically present with cutaneous and oral papillomatosis as major features of both uncommon disorders. This article details the clinical features of three patients with multiple hamartoma syndrome and one with both disorders.