Failure of elimination of amyloid-β from the brain in Alzheimer's disease

de Silva B, Prasanna Med Biol, MRCPsych
Carare, Roxana O MD, PhD
Weller, Roy O MD, PhD, FRCPath

Dr de Silva is a Consultant Psychiatrist Tees, Esk and Wear Valleys NHS Trust at Whitby Hospital (email:[email protected]), Dr Carare is a Lecturer in Anatomical Sciences, University of Southampton School of Medicine and Professor Weller is Emeritus Professor of Neuropathology, Clinical Neurosciences, University of Southampton School of Medicine

Progress in Neurology and Psychiatry 12(4):p 10, May 2008.

Accumulation of amyloid-β (Aβ) in the brain is a major cause of dementia in Alzheimer's disease. In this article, Dr de Silva, Dr Carare and Professor Weller review the mechanisms for the elimination of Aβ from the brain, the reasons why these mechanisms fail in Alzheimer's disease, and how understanding this failure may lead to new approaches to the treatment of Alzheimer's disease.