Higher frequencies of age-associated B-cells in early arthritis are linked to atherosclerosis and immune circuits—a potential role as a biomarker for risk stratification

Miranda-Prieto, Daniel
Alperi-López, Mercedes
Pérez-Álvarez, Ángel I
Alonso-Castro, Sara
Suárez, Ana
Rodríguez-Carrio, Javier

Area of Immunology, Department of Functional Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain
Basic and Translational Research on Inflammatory Diseases, Department of Metabolism, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Basic and Translational Research on Inflammatory Diseases, Department of Metabolism, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Department of Neurology, Hospital Universitario Central de Asturias, Oviedo, Spain
Basic and Translational Research on Inflammatory Diseases, Department of Metabolism, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Area of Immunology, Department of Functional Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain
Basic and Translational Research on Inflammatory Diseases, Department of Metabolism, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain
Area of Immunology, Department of Functional Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain
Basic and Translational Research on Inflammatory Diseases, Department of Metabolism, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain

Corresponding authors:Javier Rodríguez-Carrio, MSc, PhD Area of Immunology, Department of Functional Biology, Faculty of Medicine, University of Oviedo, Campus El Cristo, C/Julián Clavería s/n, L-19, 33006—Oviedo, Spain, E-mail: [email protected], Phone number: +34 98510 2789, Prof. Ana Suárez, PhD, Area of Immunology, Department of Functional Biology, Faculty of Medicine, University of Oviedo, Campus El Cristo, C/Julián Clavería s/n, L-19, 33006—Oviedo, Spain, E-mail: [email protected], Phone number: +34 98510 2789

Received January 14, 2025

Received in revised form April 25, 2025

Accepted May 23, 2025

Rheumatology Publish Ahead of Print, June 06, 2025. | DOI: 10.1093/rheumatology/keaf318