Localization of Lesion in Denial of Hemiplegia after Acute Stroke

Ellis, Simon MRCP, MD
Small, Marian PhD, CPsychol

Received April 16, 1996; final revision received July 2, 1996; accepted August 25, 1996.
From the Department of Neurology, North Staffordshire Royal Infirmary, Stoke-on-Trent (S.E.), and the MRC Research Centre in Brain and Behaviour, University Department of Clinical Neurology, The Radcliffe Infirmary, Oxford (M.S.), UK.
Correspondence to Dr Marian Small, MRC Research Centre in Brain and Behaviour, University Department of Clinical Neurology, The Radcliffe Infirmary, Woodstock Rd, Oxford, UK.

Stroke 28(1):p 67-71, January 1997.

Background and Purpose

Previous studies of lesion localization in denial of hemiplegia have often been confounded by factors such as the cerebral etiology, which aspects of the disorder are denied, and whether delusions are present. Our investigation focuses on denial of hemiplegia, without concomitant delusions, after cerebrovascular accident (CVA).

Methods

The CT scans of 30 patients with denial of hemiplegia after acute stroke were compared with those from 10 CVA patients with hemiplegia and visuospatial neglect but no denial. Lesion sites were detailed using the templates of Damasio and Damasio and, for the deep structures, those of Talairach and Tournoux.

Results

Analysis of the CT scans demonstrated that 26 of 30 denial patients had unilateral right-sided lesions and that this group showed a significantly higher incidence of lesions in deep white matter and the basal ganglia.

Conclusions

The results are discussed in relation to recent ideas regarding the role of the basal ganglia and subcortical circuits in movement and executive function. (Stroke. 1997;28:67-71.)