Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy

Tan, Mingdian PhD
Ge, Yizhi MD, PhD
Wang, Xiaogang Bsc
Wang, Yan PhD
Liu, Yi MD, PhD
He, Feng PhD
Teng, Hongqi PhD

¹School of Medicine, Asian Liver Center, Stanford, CA, USA
²The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital) and 26481, Jiangsu Institute of Cancer Research, Nanjing, China
³117850, The Third Affiliated Hospital of Soochow University, Changzhou, China
⁴Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA
⁵Stanford University School of Medicine, Stanford, CA, USA
⁶4002, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Corresponding Author: Mingdian Tan, PhD, Department of Surgery, School of Medicine, Asian Liver Center, Stanford, CA 94305, USA. Email: e-mail; [email protected]

Received January 16, 2023; revision received March 13, 2023; Accepted April 3, 2023; previously published online 4, 2023

Technology in Cancer Research and Treatment 22:p 15330338231171463, 2023. | DOI: 10.1177/15330338231171463

Abstract

In recent years, extracellular vesicles (EVs) have gained significant attention due to their tremendous potential for clinical applications. EVs play a crucial role in various aspects, including tumorigenesis, drug resistance, immune escape, and reconstruction of the tumor microenvironment. Despite the growing interest in EVs, many questions still need to be addressed before they can be practically applied in clinical settings. This paper aims to review EVs’ isolation methods, structure research, the roles of EVs in tumorigenesis and their mechanisms in multiple types of tumors, their potential application in drug delivery, and the expectations for their future in clinical research.