Systemic immunosuppression plus local production of CTLA4-Ig to control rejection of transgenic pig neuroblasts in non-human primates

¹MIRCen (Molecular Imaging Research Center/CEA, URA CEA-CNRS), Fontenay aux Roses;²INSERM U643, CHU Hotel Dieu, Nantes, France;³Immunology Laboratory, CORIT (Consortium for Research in Organ Transplantation), Legnaro, Padua;⁴Clinical Veterinary Medicine, University of Padua, Padua;⁵Department of Public Health, Comparative Pathology and Veterinary Hygiene, University of Padua, Padua;⁶Department of Infectious Diseases, Padua University Hospital, Padua;⁷Department of Neurosciences, University of Padua, Padua, Italy;⁸Department of Physio Reproduction, INRA, Nouzilly, France;⁹Department of Nuclear Medicine, S. Maria della Misericordia Hospital, Rovigo;¹⁰Department of Surgery and Transplantation, Padua University Hospital, Padua, Italy