Publication Year: 2017
Edition: 1st Ed.
Authors/Editor: Gray, Juliet C.; Marabelle, Aurélien
Doody's Star Rating®:Score: 100
Comprehensively reviews immunotherapy strategies currently used in the treatment of cancer and how these are applicable to pediatric malignancies
Addresses key issues, such as immune-related toxicities, and practical challenges for delivery in the pediatric population
Discusses how current therapies may be optimized and improved, and how they may be incorporated into existing treatment regimens
This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.
Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.
Immunotherapy for Pediatric Malignancies