Clustal W and Clustal X version 2.0

Larkin, M.A.
Blackshields, G.
Brown, N.P.
Chenna, R.
McGettigan, P.A.
McWilliam, H.
Valentin, F.
Wallace, I.M.
Wilm, A.
Lopez, R.
Thompson, J.D.
Gibson, T.J.
Higgins, D.G.

¹The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
²Laboratoire de Biologie et Genomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
³European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
⁴EMBL Outstation-European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD, UK

Received on June 27, 2007; revised on August 3, 2007; accepted on August 3, 2007; Advance Access publication September 10, 2007

Associate Editor: Alex Bateman

Availability: The programs can be run on-line from the EBI web server: http://www.ebi.ac.uk/tools/clustalw2. The source code and executables for Windows, Linux and Macintosh computers are available from the EBI ftp site ftp://ftp.ebi.ac.uk/pub/software/clustalw2/

Contact: [email protected]

^*To whom correspondence should be addressed.

Bioinformatics 23(21):p 2947-2948, November 1, 2007.

Summary

The Clustal W and Clustal X multiple sequence alignment programs have been completely rewritten in C++. This will facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems.