ASEdb

a database of alanine mutations and their effects on the free energy of binding in protein interactions

Thorn, Kurt S.
Bogan, Andrew A.

Graduate Group in Biophysics, University of California, San Francisco, CA 94143, USA

^*To whom correspondence should be addressed.

Received on October 10, 2000; revised on November 3, 2000; accepted on November 13, 2000

Bioinformatics 17(3):p 284-285, March 2001.

Summary

The Alanine Scanning Energetics database (ASEdb) is a searchable database of single alanine mutations in protein–protein, protein–nucleic acid, and protein–small molecule interactions for which binding affinities have been experimentally determined. In cases where structures are available, it contains surface areas of the mutated side chain and links to the PDB entries. It is useful for studying the contribution of single amino acids to the energetics of protein interactions, and can be updated by researchers as new data are generated.

Availability

ASEdb is accessible on the Web at http://www.asedb.org

Contact

[email protected]