Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis
- Tang, Xuelin
- Chen, Yan
- Ren, Yongfei
- Yang, Wanli
- Yu, Wendi
- Zhou, Yu
- Guo, Jingyan
- Hu, Jiali
- Chen, Xi
- Gu, Yuqi
- Wang, Chuyi
- Dong, Yi
- Yang, Hong
- Sato, Christine
- He, Ji
- Fan, Dongsheng
- You, Linya
- Zinman, Lorne
- Rogaeva, Ekaterina
- Chen, Yelin
- Zhang, Ming
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200090, China
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5T 0S8, Canada
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200040, China
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
School of Software Engineering, Tongji University, Shanghai 200127, China
Department of Computer Science & Engineering, Texas A&M University, College Station, TX 77843, USA
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200090, China
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200090, China
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200040, China
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200090, China
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200040, China
The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200090, China
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5T 0S8, Canada
Department of Neurology, Peking University Third Hospital, Beijing 100191, China
Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Peking University Third Hospital, Beijing 100191, China
Department of Neurology, Peking University Third Hospital, Beijing 100191, China
Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Peking University Third Hospital, Beijing 100191, China
Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
Division of Neurology, University of Toronto, Toronto, Ontario M5S 3H2, Canada
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5T 0S8, Canada
Division of Neurology, University of Toronto, Toronto, Ontario M5S 3H2, Canada
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200331, China
The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200090, China
Institute for Advanced Study, Tongji University, Shanghai 200092, China
Correspondence to: Ming Zhang State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Clinical Center for Brain and Spinal Cord Research, School of Medicine, Tongji University, 500 ZhenNan Road, Shanghai 200331, China E-mail: [email protected]
Xuelin Tang, Yan Chen and Yongfei Ren contributed equally to this work.
Received September 18, 2024
Received in revised form December 04, 2024
Accepted January 05, 2025
Revised May 05, 2025
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
