A Model of Tobacco Smoke-Induced Airflow Obstruction in the Guinea Pig*

Wright, Joanne L. MD
Churg, Andrew MD

*From the Department of Pathology, University of British Columbia, Vancouver, BC, Canada.

This research was supported by grants from the Medical Research Council/Canadian Institutes of Health Research and the Heart and Stroke Foundation of British Columbia and Yukon.

Correspondence to: Joanne L. Wright, MD, Department of Pathology, University of British Columbia, 2211 Westbrook Mall, Vancouver, BC, V6T 2B5 Canada; e-mail: [email protected]

Chest 121(5):p 188S-191S, May 2002.

Animal models have proven to be extremely worthwhile in the investigations of cigarette smoke-induced lung disease. We have found the guinea pig to be useful, with a large number of advantages and few disadvantages when used in our experimental circumstances. Other animal models exist, however, and the investigator should select the model that is most suited to the hypothesis to be tested.