Statins Plus Ezetimibe vs. Statins Alone

Crawford, Michael H. MD

Editor

Clinical Cardiology Alert 41(10):p 77-78, October 2022.

SYNOPSIS:

A comparison of rosuvastatin 10 mg/day plus ezetimibe (10 mg/day) to 20 mg/day of rosuvastatin alone showed non-inferiority in three-year major cardiovascular outcomes, with lower LDL cholesterol levels and fewer episodes of drug discontinuation or dose reductions in the combination therapy group.

SOURCE:

Kim BK, Hong SJ, Lee YJ, et al. Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): A randomized, open-label, noninferiority trial. Lancet 2022;400:380-390.