2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis
Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People
- Baddley, John W
- Wolf, Joshua
- Ardura, Monica I
- Badreldin, Nevert
- Bahr, Nathan C
- Bloch, Karen
- Kauffman, Carol A
- Lentz, Robert J
- Miller, Rachel A
- Mocherla, Satish
- Pappas, Peter
- Saccente, Michael
- Schwartz, Ilan
- Stover, Kayla R
- Wiederhold, Nathan P
- Loveless, Jennifer
- Spec, Andrej
- Arnold, Sandra R
Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Pediatric Infectious Diseases & Host Defense, Nationwide Children's Hospital, Columbus, Ohio, USA
Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
Department of Obstetrics & Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Division of Infectious Diseases, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Division of Allergy, Pulmonary & Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Division of Infectious Diseases, Duke University, Durham, North Carolina, USA
Division of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Division of Infectious Diseases, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Division of Infectious Diseases, Duke University, Durham, North Carolina, USA
Department of Pharmacy Practice, University of Mississippi, Jackson, Mississippi, USA
Department of Pathology and Laboratory Medicine, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Clinical Affairs and Practice Guidelines, Infectious Diseases Society of America, Arlington, Virginia, USA
Division of Infectious Diseases, Washington University in St. Louis, St. Louis, Missouri, USA
Department of Pediatrics, Le Bonheur Children's Hospital, Memphis, Tennessee, USA
University of Tennessee Health Science Center, Memphis, Tennessee, USA
John W. Baddley and Joshua Wolf contributed equally to the manuscript.
Jennifer Loveless, Andrej Spec and Sandra R. Arnold contributed equally to the manuscript.
Correspondence: S. R. Arnold, Le Bonheur Children's Hospital, 49 N Dunlap St, Room 293, Memphis, TN 38105 ([email protected]).
Possible conflicts of interest. Evaluation of relationships as potential conflicts of interest (COIs) is determined by a review process. The assessment of disclosed relationships for possible COIs is based on the relative weight of the financial relationship (ie, monetary amount) and the relevance of the relationship (ie, the degree to which an association might reasonably be interpreted by an independent observer as related to the topic or recommendation of consideration). The following panelists have scientific advisory/consultant roles related to the topic (ie, manageable conflicts of interest): A. S. (vice chair) with Mayne and Scynexis, C. A. K. with Cidara Therapeutics (concluded) and Laboratoires SMB S. A. (concluded), K. S. with Cidara Therapeutics (concluded), and N. W. with F2G (concluded). C. A. K. is Editor-in-Chief for UpToDate's Infectious Diseases sections, and J. B. is an editor for UpToDate's Fungal Infections sections. The following panelists have research relationships related to the topic: A. S. (vice chair) with Astellas; R. M. with Scynexis and F2G; P. P. with Mayne; N. W. with F2G, Scynexis, Mycovia (concluded), and Sfunga (concluded). No disclosures were reported for all other authors (the majority of panelists) including chair. All other authors report no potential conflicts.
All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Received March 20, 2025
Revised July 08, 2025
