Empagliflozin inhibits excessive autophagy through the AMPK/GSK3β signalling pathway in diabetic cardiomyopathy

Madonna, Rosalinda
Moscato, Stefania
Cufaro, Maria Concetta
Pieragostino, Damiana
Mattii, Letizia
Del Boccio, Piero
Ghelardoni, Sandra
Zucchi, Riccardo
De Caterina, Raffaele

Cardiology Division, Department of Pathology, University of Pisa, Via Paradisa, 56124 Pisa, Italy
Histology Division, Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy
Department of Pharmacy, ‘G. d’Annunzio’ University of Chieti-Pescara, Via Colle dell'Ara, 56100 Chieti, Italy
Analytical Biochemistry and Proteomics Laboratory, Center for Advanced Studies and Technology (CAST), ‘G. d’Annunzio’ University of Chieti-Pescara, Via Colle dell'Ara, 56100 Chieti, Italy
Analytical Biochemistry and Proteomics Laboratory, Center for Advanced Studies and Technology (CAST), ‘G. d’Annunzio’ University of Chieti-Pescara, Via Colle dell'Ara, 56100 Chieti, Italy
Department of Innovative Technologies in Medicine and Dentistry, ‘G. d’Annunzio’ University of Chieti-Pescara, Via Colle dell'Ara, 56100 Chieti, Italy
Histology Division, Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, 56126 Pisa, Italy
Department of Pharmacy, ‘G. d’Annunzio’ University of Chieti-Pescara, Via Colle dell'Ara, 56100 Chieti, Italy
Analytical Biochemistry and Proteomics Laboratory, Center for Advanced Studies and Technology (CAST), ‘G. d’Annunzio’ University of Chieti-Pescara, Via Colle dell'Ara, 56100 Chieti, Italy
Department of Pathology, Laboratory of Biochemistry, University of Pisa, Via Savi 10, 56126 Pisa, Italy
Department of Pathology, Laboratory of Biochemistry, University of Pisa, Via Savi 10, 56126 Pisa, Italy
Cardiology Division, Department of Pathology, University of Pisa, Via Paradisa, 56124 Pisa, Italy

Corresponding author. Tel: +39 050 2212111, Emails: [email protected] (R.D.C.); [email protected] (R.M.)

Rosalinda Madonna and Stefania Moscato contributed equally to this work.

Conflict of interest: The authors declare that the research was conducted in the absence of any conflict of interest.

Received June 27, 2022

Received in revised form November 23, 2022

Accepted December 09, 2022

Revised January 24, 2023

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Cardiovascular Research 119(5):p 1175-1189, May 2023. | DOI: 10.1093/cvr/cvad009