A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery
- Hirsch, Irl B.
- Beck, Roy W.
- Marak, Martin Chase
- Calhoun, Peter
- Mottalib, Adham
- Salhin, Amna
- Manessis, Anastasios
- Coviello, Andrea D.
- Bhargava, Anuj
- Thorsell, Ashley
- Atakov Castillo, Astrid
- Bode, Bruce W.
- Levister, Camilla
- Levy, Carol J.
- Donahue, Cassandra
- Cordero, Christian
- Beatson, Christie
- Langel, Christine R.
- Jacobson, Christopher
- Kurek, Corey
- Cruse, Dana
- Pickering, David
- Tamarez, Denisa
- Steenkamp, Devin W.
- Desjardins, Donna
- Aleppo, Grazia
- O’Malley, Grenye
- Akturk, Halis K.
- Diner, Jamie
- Baran, Jesica D.
- Buse, John B.
- Ruedy, Katrina
- Codorniz, Kevin
- Klein, Klara R.
- Castorino, Kristin
- Jordan, Lin Fan
- Kipnes, Mark
- Church, Mei Mei
- Hamdy, Osama
- Raskin, Philip
- Nguyen, Quang T.
- Weinstock, Ruth S.
- Lee, Scott
- Rizvi, Shafaq
- Bzdick, Suzan
- Ghorbani Rodriguez, Tahereh
- Salah, Tareq
- Blevins, Thomas
- Kudva, Yogish C.
- Haider, Zehra
- Bode, Bruce W.
- Ownby, Jonathan
- Johnson, Joseph
- Ruiz, Adriana
- Stephens, Nashia
- Maxson, Amanda
- Akturk, Halis K.
- Haider, Zehra
- Beatson, Christie
- Mason, Emma
- Steenkamp, Devin W.
- Wolpert, Howard
- Atakov-Castillo, Astrid
- Sullivan, Asya
- Kipnes, Mark
- Salhin, Amna
- Copple, Tina
- Beltran, Stephanie
- Ryan, Terri
- Levy, Carol J.
- O’Malley, Grenye
- Levister, Camilla
- Tamarez, Denisa
- Ipek, Aslihan
- Bhargava, Anuj
- Burke, Christine
- Langel, Christine
- Bauman, Shannon
- Haight, Cristina
- Bohr, Allie
- Hamdy, Osama
- Mottalib, Adham
- Salah, Tareq
- Al Badri, Marwa
- Dhaver, Shilton
- Nguyen, Quang T.
- Nguyen, Loida
- Codorniz, Kevin
- Lee, Scott
- Jacobson, Christopher
- Cordero, Christian
- Migliozzi, Brittney
- Kudva, Yogish
- Desjardins, Donna
- Reid, Corey
- Rizvi, Shafaq
- Kaur, Ravinder Jeet
- Livingood, Daine
- Pickering, David
- Cruse, Dana
- Aleppo, Grazia
- Kravarusic, Jelena
- Coyne, Kasey
- Herrmann, Stefanie
- Fronczyk, Evelyn
- Manessis, Anastasios
- McKillop, Lorcan
- Hyatt, Jamie
- Patruno, Maria
- Castorino, Kristin
- Church, Mei Mei
- Thorsell, Ashley
- Shuirman, Maggie
- Cobb, Brandon
- Watt, Olivia
- Weinstock, Ruth
- Bzdick, Suzan
- Blevins, Thomas
- Casaubon, Luis
- Espinosa, Valerie
- Pandit, Keta
- Perez, Jennifer
- Armstrong, Chloe
- Martinez-Arredondo, Maritza
- Stewart, Ana
- Johnson, Olivia
- Diner, Jamie
- Buse, John
- Klein, Klara
- Ghorbani Rodriguez, Tahereh
- Young, Laura
- Coviello, Andrea D.
- Donahue, Cassandra
- Kass, Alexander
- Fulghum, Karla
- Raskin, Philip
- Jordan, Lin
- Shao, Baomei
- Hirsch, Irl B.
- Baran, Jesica
- Mandava, Patali
- Holod, Rosanna
- Kaiserman, Kevin
- Ulloa, Johanna
- Pleitez, Jennifer
- Sylvan, Joey
- Badgett, Lynn
- Ruedy, Katrina
- Beck, Roy
- Borgman, Sarah
- Frey, Sarah
- Mba-Oduwusi, Nnenna
- Miller, Paige
- Fults, Ashleigh
- Marak, Martin
- Calhoun, Peter
- Pritchard, Rosa
- Dolzhenko, Elizaveta
- McCarthy, Chris
- Gabrielson, Deanna
- Brown, Sue
- Ahmann, Andrew
- Bergenstal, Richard
OBJECTIVE
To compare postprandial glucose excursions following a bolus with inhaled technosphere insulin (TI) or subcutaneous rapid-acting analog (RAA) insulin.
RESEARCH DESIGN AND METHODS
A meal challenge was completed by 122 adults with type 1 diabetes who were using multiple daily injections (MDI), a nonautomated pump, or automated insulin delivery (AID) and who were randomized to bolus with their usual RAA insulin (n = 61) or TI (n = 61).
RESULTS
The primary outcome, the treatment group difference in area under the curve for glucose >180 mg/dL over 2 h, was less with TI versus RAA (adjusted difference −12 mg/dL, 95% CI −22 to −2, P = 0.02). With TI, the glucose excursion was smaller (P = 0.01), peak glucose lower (P = 0.01), and time to peak glucose shorter (P = 0.006). Blood glucose <70 mg/dL occurred in one participant in each group.
CONCLUSIONS
Postmeal glucose excursion was smaller with TI than with RAA insulin in a cohort that included both AID and MDI users.