Parkinson’s disease and enhanced inflammatory response

Stojkovska, Iva
Wagner, Brandon M
Morrison, Brad E

¹Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA

Brad E Morrison. Email: [email protected]

Received November 20, 2014

Accepted January 21, 2015

Experimental Biology & Medicine 240(11):p 1387-1395, November 2015. | DOI: 10.1177/1535370215576313

Parkinson’s disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a loss of midbrain dopaminergic (DA) neurons. However, the molecular cause of DA neuron loss remains elusive. Mounting evidence implicates enhanced inflammatory response in the development and progression of PD pathology. This review examines current research connecting PD and inflammatory response.