Multipoint maximum likelihood mapping in a full-sib family of an outbreeding species

VAN OOIJEN, J. W.

Kyazma B.V., P. O. Box 182, 6700 AD Wageningen, the Netherlands

^* Corresponding author: Kyazma B.V., P. O. Box 182, 6700 AD Wageningen, the Netherlands. Email: [email protected]

Hans Jansen of Biometris and Chris Maliepaard of Wageningen University are thanked for their comments on earlier versions of the manuscript. The work for this paper was financed by Kyazma B.V.

(Received 15 December 2010; revised 15 April 2011 and 15 June 2011; accepted 15 June 2011; first published online 31 August 2011)

Genetical Research 93(5):p 343-349, October 2011.

Summary

The fast multipoint maximum likelihood mapping algorithm for crosses between inbred lines, introduced by , is extended for mapping in a full-sib family of an outbreeding species. The method accommodates different segregation types of markers and differences in recombination between parents. The two separate parental multipoint maximum likelihood maps are joined into an integrated map by averaging lengths over anchored segments and by interpolating or extrapolating for markers segregating in one parent only. The method is illustrated with simulated data. The method will enable a more accurate estimation of maps in outbreeding species than current methods.