Predictors of Complicated Disease Course in Adults and Children With Crohn’s Disease

A Nationwide Study from the epi-IIRN

Atia, Ohad MD
Lujan, Rona MA
Buchuk, Rachel MA
Greenfeld, Shira MD
Kariv, Revital MD
Loewenberg Weisband, Yiska MD
Ledderman, Natan MD
Matz, Eran MD
Ledder, Oren MD
Zittan, Eran MD
Yanai, Henit MD
Shwartz, Doron MD
Dotan, Iris MD, PhD
Nevo, Daniel PhD
Turner, Dan MD, PhD

Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel
Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel
Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel
Maccabi Health Services, Tel Aviv, Israel
Sackler Faculty of Medicine, Tel Aviv University, Israel
Maccabi Health Services, Tel Aviv, Israel
Sackler Faculty of Medicine, Tel Aviv University, Israel
Clalit Health Services, Clalit Research Institute, Tel Aviv, Israel
Meuhedet Health Services, Tel Aviv, Israel
Leumit Health Services, Tel Aviv, Israel
Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel
The Abraham and Sonia Rochlin IBD Unit, Institute of Gastroenterology and Liver Diseases, Emek Medical Center, Afula, Israel
The Rappaport Faculty of Medicine Technion-Israel Institute of Technology, Haifa, Israel
Division of Gastroenterology, Rabin Medical Center, Petah Tikva and the Faculty of Medicine, Tel Aviv University, Israel
Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer- Sheva, Israel
Division of Gastroenterology, Rabin Medical Center, Petah Tikva and the Faculty of Medicine, Tel Aviv University, Israel
Department of Statistics and Operations Research, Tel Aviv University, Israel
Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel

Address correspondence to: Dan Turner, MD, PhD, The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, The Hebrew University School of Medicine, P.O. Box 3235, Jerusalem 9103102, Israel, Tel: +972-50-868-5841; Fax: +972-2-655-5756 ([email protected]).

Ohad Atia, Rona Lujan and Rachel Buchuk Equal contribution

Received October 21, 2023

Revised February 08, 2024

Online date: February 08, 2024

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Inflammatory Bowel Diseases 30(12):p 2370-2379, December 05, 2024. | DOI: 10.1093/ibd/izae014

Lay Summary

Prognostic factors of complicated disease course are vital for considering early escalation to biologics. In this nationwide cohort, complicated disease course was apparent in approximately one-fourth of patients and was predicted particularly by routinely collected laboratory tests, age, and type of induction therapy at diagnosis.