Adeno-Associated Virus 2 May Be the Cause of Unexplained Hepatitis in Children

Winslow, Dean L. MD, MACP, FIDSA, FPIDS

Professor of Medicine, Division of General Medical Disciplines, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine

Infectious Disease Alert 41(12):p 140-141, September 2022.

SYNOPSIS: With next-generation sequencing and real-time polymerase chain reaction, researchers detected adeno-associated virus 2 (AAV2) in the plasma of 9/9 patients and in the liver of 4/4 patients but not in healthy controls, children with adenovirus infection and normal liver function, or children admitted to the hospital with hepatitis of another etiology.

SOURCE: Ho A, Orton R, Tayler R, et al. Adeno-associated virus 2 infection in children with non-A-E hepatitis. medRxiv. https://www.medrxiv.org/content/10.1101/2022.07.19.22277425v1.full-text