Is It Better to Up-Titrate Medications Faster in Acute Heart Failure Patients?

Crawford, Michael H. MD

Professor of Medicine, Lucy Stern Chair in Cardiology, University of California, San Francisco

Internal Medicine Alert 45(2):p 10-12, January 30, 2023.

SYNOPSIS: Early intensive up-titration of guideline-recommended therapy in patients admitted for heart failure reduced 180-day readmission and all-cause mortality rates at the cost of more adverse events (but not serious or fatal ones).

SOURCE: Mebazaa A, Davison B, Chioncel O, et al. Safety, tolerability and efficacy of up-titration of guideline directed medical therapies for acute heart failure (STRONG-HF): A multinational, open-label, randomised, trial. Lancet 2022;400:1938-1952.