Review Article

Therapeutic Effects of Quercetin on Renal Fibrosis and Injury

  • Wang, Wenbiao1
  • Wu, Wenjing5

  • 1

    Medical Research Center, Guangdong Academy of Medical Science, Guangdong Provincial People’s Hospital, Southern Medical University, Guangzhou 510000, China

  • 2

    Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan 430000, China.

  • 3

    Hubei Key Laboratory of theory and application research of liver and kidney in traditional Chinese medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430000, China.

  • 4

    Hubei Shizhen Laboratory, Wuhan 430000, China.

  • 5

    Hubei Province Academy of Traditional Chinese Medicine, Wuhan 430000, China
Address for correspondence: Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine. E-mail: [email protected]

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Integrative Medicine in Nephrology and Andrology 12(1), March 2025. | DOI: 10.1097/IMNA-D-24-00051

Quercetin is a natural flavonoid found in a variety of herbs and is the main active ingredient in several herbal formulas for treating kidney disease. Numerous studies have shown that quercetin can effectively attenuate acute kidney injury (AKI) by inhibiting renal inflammation, ferroptosis, and cell apoptosis. Quercetin ameliorates renal fibrosis in chronic kidney disease (CKD) by attenuating epithelial-to-mesenchymal transition, inflammation, cellular senescence, and other mechanisms. Therefore, quercetin may be a potential drug for the treatment of kidney diseases. In this review, recent advances in the therapeutic effects on and the mechanisms of quercetin in AKI and CKD are discussed.

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