Rhinosinusitis

Establishing definitions for clinical research and patient care

Meltzer, Eli O. MD
Hamilos, Daniel L. MD
Hadley, James A. MD
Lanza, Donald C. MD
Marple, Bradley F. MD
Nicklas, Richard A. MD
Bachert, Claus MD, PhD
Baraniuk, James MD
Baroody, Fuad M. MD
Benninger, Michael S. MD
Brook, Itzhak MD
Chowdhury, Badrul A. MD, PhD
Druce, Howard M. MD
Durham, Stephen MD
Ferguson, Berrylin MD
Gwaltney, Jack M. Jr. MD
Kaliner, Michael MD
Kennedy, David W. MD
Lund, Valerie MD
Naclerio, Robert MD
Pawankar, Ruby MD, PhD
Piccirillo, Jay F. MD
Rohane, Patricia MD
Simon, Ronald MD
Slavin, Raymond G. MD, MS
Togias, Alkis MD
Wald, Ellen R. MD
Zinreich, S. James MD

^aDepartment of Pediatrics, Allergy and Asthma Medical Group and Research Center, University of California, San Diego, Calif
^bDivision of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, Mass
^cDepartment of Otolaryngology-Head and Neck Surgery, University of Rochester, Rochester, NY
^dSinus and Nasal Institute of Florida, St. Petersburg, Fla
^eDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Tex
^fDepartment of Medicine, George Washington University, Washingtion, DC
^gENT Department, Universitair Ziekenhuis Ghent, Ghent, Belgium
^hDepartment of Medicine, Georgetown University, Washington, DC
ⁱDepartment of Otolaryngology–Head and Neck Surgery and Pediatrics, University of Chicago, Chicago, Ill
^jDepartment of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, Mich
^kDepartment of Pediatrics and Medicine, Georgetown University, Washington, DC
^lDepartment of Allergy and Immunology, Walter Reed Army Medical Center, Washington, DC
^mDepartment of Medicine, the Division of Allergy/Immunology, UMDNJ-New Jersey Medical School, Newark, NJ
ⁿDepartment of Allergy and Respiratory Medicine, National Heart & Lung Institute, Imperial College, London, United Kingdom
^oDivision of Sino-nasal Disorders and Allergy, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pa
^pDivision of Epidemiology and Virology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Va
^qGeorge Washington University, School of Medicine, Institute for Asthma and Allergy, Wheaton, Md
^rDepartment of Otolaryngology, University of Pennsylvania, Philadelphia, Pa
^sDepartment of Otolaryngology, University College London, London, United Kingdom
^tDepartment of Otolaryngology–Head and Neck Surgery, University of Chicago, Department of Surgery, Chicago, Ill
^uDepartment of Otolaryngology, Nippon Medical School, Tokyo, Japan
^vDepartment of Otolaryngology and Medicine, Washington University, School of Medicine, St Louis, Mo
^wClinical Development-Inflammation, Celgene Corp, Warren, NJ
^xDivision of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, Calif
^yDepartment of Internal Medicine, St Louis University, School of Medicine, St Louis, Mo
^zDepartment of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Md
^aaDepartment of Pediatrics and Otolaryngology, University of Pittsburgh, School of Medicine, Pittsburgh, Pa
^bbDepartment of Radiology and Radiologic Science-Neuroradiology, Johns Hopkins University, School of Medicine, Baltimore, Md.

Reprint requests: Eli O. Meltzer, MD, Allergy and Asthma Medical Group and Research Center, 9610 Granite Ridge Drive, Suite B, San Diego, CA 92123. E-mail: [email protected].

This document was edited by Dr Nicklas in his private capacity and not in his capacity as a Medical Officer with United States Food and Drug Administration (FDA). No official support or endorsement by the FDA is intended or should be inferred.

Disclosure of potential conflict of interest: E. O. Meltzer has consulting arrangements with Alcon, Altana, AstraZeneca, Aventis, Dey, Genentech, GlaxoSmithKline, Merck, Medpointe, Novartis, Pfizer, Schering-Plough, and Wyeth; receives grants–research Support from Alcon, Altana, AstraZeneca, Aventis, Dey, Genetech, GlaxoSmithKline, Merck, Novartis, Pfizer, and Schering-Plough; and is on the Speakers' Bureau for Aventis, AstraZeneca, Genentech, GlaxoSmithKline, Merck, Pfizer, and Schering-Plough. D. L. Hamilos—none disclosed. J. A. Hadley has consultant arrangements with Abbott, Aventis, Bayer, GlaxoSmithKline, Merck, GE Medical Systems, Pfizer, and Schering-Plough; and is on the Speaker's Bureau for Abbott, Aventis, Bayer, GlaxoSmithKline, Merck, Pfizer, and Schering-Plough. D. Lanza is on the Speaker's Bureau for AstraZeneca. B. F. Marple has consulting arrangements with Alcon, Aventis, and Bayer and receives grants-research support from Aventis, GlaxoSmithKline, Abbott, Merck, and Bayer. R. A. Nicklas—none disclosed. C. Bachert—none disclosed. J. Baraniuk has consultant arrangements with Roche, Centecor, GlaxoSmithKline, Astra-Zeneca, and Aventis; has patent-licensing arrangements with Georgetown University; receives grants-research support from the National Institutes of Health; and is employed by Georgetown University. F. M. Baroody is on the Speaker's Bureau for Merck & Co, Inc, and GlaxoSmithKline. M. S. Benninger has consultant arrangements with Aventis, GlaxoSmithkline, Ortho-McNeil, Abbott, and Bayer; receives grants–research support from Novartis and Bayer; is on the Speaker's Bureau for Aventis and GlaxoSmithKline. I. Brook is on the Speaker's Bureau for Abbott. B. A. Chowdhury—none disclosed. H. M. Druce is employed by Phys Inc. S. Durham has consultant arrangements with ALK Abello, UCB, and GlaxoSmithKline; receives grants–research support from ALK Abello and GalxoSmithKline; and is on the Speaker's Bureau for ALK Abello, UCB, Aventis, and WAO. B. Ferguson has consulting arrangements with Aventis, Abbot, and GlaxoSmithKline; is on the Speaker's Bureau for Aventis, Astra Zeneca, Abbott, Merck, GlaxoSmithKline, and Pfizer; and is an advisor for Pfizer. J. M. Gwaltney, Jr—none disclosed. M. Kaliner has consultant arrangements with Aventis, Novartis, GlaxoSmithKline, Genetech, and Abbott; receives grants–research support from Astra Zeneca, Aventis, Boehringher-Ingelheim, GlaxoSmithKline, and Schering-Plough; and is on the Speaker's Bureau for Aventis, Abbott, GlaxoSmithKline, Medpointe, Novartis, and Genetech. D. Kennedy has consulting arrangements with Aventis, Novartis, Medtronic-Xomed, and Schering-Plough; received grants–research support from Novartis; and has patent-licensing arrangements with Medtronic-Xomed. V. Lund has consulting arrangements with Schering-Plough and Bayer. R. Naclerio has consulting arrangements with Merck and Schering-Plough; receives grants–research support from Corixa and Merch; and is on the Speaker's Bureau for Merck and GlaxoSmithKline. R. Pawankar—none disclosed. J. F. Piccirillo—none disclosed. P. Rohane is employed by Celgene Corp. R. Simon—none disclosed. R. Slavin has consultant arrangements with Aventis; receives grants–research support from GlaxoSmithKline, Genentech, and AstraZeneca; and is on the Speaker's Bureau of Aventis, Schering-Plough, Genentech, and AstraZeneca. A. Togias has consultant arrangement with AstraZeneca, Genentech, GlaxoSmithKline, Novartis, and Merck; receives grants–research support from Merck and Genentech; and is on the Speaker's Bureau for Genentech, Merck, Novartis, Pfizer, and UCB. E. R. Wald receives grants—research support from Aventis, GlaxoSmithKline, Wyeth, Abbott, and Medimmune. J. Zinreich—none disclosed.

Journal of Allergy & Clinical Immunology 114(6):p S155-S212, December 2004.