Therapeutic drug monitoring of vancomycin

a guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society

Ye, Zhi-Kang
Chen, Yao-Long
Chen, Ken
Zhang, Xiang-Lin
Du, Guan-Hua
He, Bei
Li, Da-Kui
Liu, You-Ning
Yang, Ke-Hu
Zhang, Ying-Yuan
Zhai, Suo-Di
Du, Guan-Hua
He, Bei
Li, Da-Kui
Liu, You-Nin
Yang, Ke-Hu
Zhang, Xiang-Lin
Zhang, Ying-Yuan
Zhai, Suo-Di
Chen, Xiao
Chen, Yao-Long
Du, Guang
Gu, Jian
Guo, Dai-Hong
Guo, Rui-Chen
Hu, Xin
Li, Huan-De
Liu, Gao-Lin
Lv, Yuan
Lu, Wei
Miao, Li-Yan
Qu, Jie-Ming
Sun, Tie-Ying
Tong, Rong-Sheng
Wang, Li
Wang, Rui
Wang, Zhi-Guo
Wen, Ai-Dong
Wu, Jiu-Hong
Wu, Xin-An
Xu, Ying-Chun
Zhan, Si-Yan
Zhang, Hui-Zhi
Zhang, Jie
Zhang, Jing
Zhang, Jun
Zhao, Li-Mei
Zhao, Rong-Sheng
Zhao, Zhi-Gang
Ye, Zhi-Kang
Chen, Ken
Men, Peng
Zhou, Jun-Wen
Dong, Qian-Ru
Xie, Ran
Jiao, Rui
Xu, Yang
Zhao, Xi-Lan
Xue, Jing-Yi

¹Department of Pharmacy, Peking University Third Hospital, Beijing, China
²Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Gansu, China
³Chinese GRADE Center, Gansu, China
⁴Pharmaceutical Department of China-Japan Friendship Hospital, Beijing, China
⁵Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, China
⁶Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China
⁷Pharmacy Department, Peking Union Medical College Hospital, Beijing, China
⁸Institute of Respiratory Disease, Chinese PLA General Hospital, Beijing, China
⁹Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University, Shanghai, China

Corresponding author. Tel: +010-82266686; Fax: +010-82266686; E-mail: [email protected]

† Members are listed in the Acknowledgements section.

Journal of Antimicrobial Chemotherapy 71(11):p 3020-3025, November 2016. | DOI: 10.1093/jac/dkw254

Background

Guideline development should be based on the quality of evidence, balance of benefits and harms, economic evaluation and patients’ views and preferences. Therefore, these factors were considered in the development of a new guideline for therapeutic drug monitoring (TDM) of vancomycin.

Objectives

To develop an evidence-based guideline for vancomycin TDM and to promote standardized vancomycin TDM in clinical practice in China.

Methods

We referred to the WHO Handbook for Guideline Development and used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to rate the quality of evidence and grade the strength of recommendations, according to economic evaluation and patients’ views and preferences. We used the GRADE Grid method to formulate the recommendations.

Results

The guideline presents recommendations about who should receive vancomycin TDM, how to monitor vancomycin efficacy and renal safety, therapeutic trough concentrations, time to start initial vancomycin TDM, loading dose and how to administer and adjust the vancomycin dose.

Conclusions

We developed an evidence-based guideline for vancomycin TDM, which provides recommendations for clinicians and pharmacists to conduct vancomycin TDM in China.