Adenosine triphosphate/pH dual-responsive controlled drug release system with high cancer/normal cell selectivity and low side toxicity

Fu, Bo
Lin, Hui-Chao
Chen, Nian
Zhao, Ping

¹College of Health Industry, Zhongshan Torch Polytechnic, Zhongshan, China
²71237School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, China

Ping Zhao, School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangdong, 510006, China Email: [email protected]

Bo Fu, College of Health Industry, Zhongshan Torch Polytechnic, Guangdong, China. Email: [email protected]

# Bo Fu and Hui-Chao Lin contributed equally to this work.

Journal of Biomaterials Applications 37(2):p 324-332, August 2022. | DOI: 10.1177/08853282221087412

Most drug-delivery systems (DDS) suffer from poor selectivity to cancer/normal cells or the complicated synthetic process. Herein, we employed a novel facile method to develop an oligodeoxy nucleotides based DDS composed with adenosine-5^′- triphosphate (ATP) aptamer and a pH responsive cytosine (C) DNA fragment for specific daunomycine (DNM) delivery. The DDS has ATP/pH dual-responsive drug release, can selectively internalize into tumor cell lines and thus has ultrahigh cancer/normal cell selectivity over the individual drug. The non-chemical synthesis, controllable dual-responsive intracellular drug release, and high cancer/normal cell selectivity endowed the DDS high biocompatibility and significant tumor suppression.