Gelatin-loaded cubosomes stabilized with hydrophobically modified quaternized cellulose nanofiber and their pH-dependent release property

Park, Seok Ho
Zhao, Fanyu
Park, Soo Chan
Kim, Jin-Chul

Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea ^*These authors contributed equally to this study.

Jin-Chul Kim, Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 24341, Republic of Korea. Email: [email protected]

Journal of Biomaterials Applications 35(9):p 1109-1118, April 2021. | DOI: 10.1177/0885328221995924

Monoolein cubic phase immobilizing hydrophobically modified gelatin (HmGel) in its water channel was prepared by a melt-hydration method. The cubic phase was micronized into cubosomes by using hydrophobically modified quaternized cellulose nanofiber (HmQCNF) as a stabilizer. The phase transition temperature of the cubic phase was about 68–70 °C. Small angle X-ray diffraction revealed that HmGel-loaded cubosome stabilized with HmCNF was a diamond type of cubic phase. HmGel-loaded cubosomes stailized with HmQCNF were dependent on the pH value in terms of the release of their payload (i.e, methylene blue) much more strongly than HmGel-loaded cubosomes stabilized with Pluronic F127.