Department of Medicine (S.M.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Molecular and Clinical Endocrinology and Oncology (A.C.), Federico II University of Naples, 80138 Naples, Italy; Division of Endocrinology and Metabolism (A.B.), University of Michigan Medical Center, Ann Arbor, Michigan 48109; Endocrinology Clinic (M.M.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; Department of Endocrinology (A.B.G.), St. Bartholomew’s Hospital, London EC1A 7BE, United Kingdom; Department of Medicine (D.K.), New York University Medical Center, New York, New York 10016; Division of Endocrinology (D.C.), University of North Carolina, Chapel Hill, North Carolina 27599; Assistance Publique-Hôpitaux de Paris (P.C.), Department of Endocrinology and Reproductive Diseases, Hôpital de Bicêtre and Université Paris-Sud 11, Le Kremlin-Bicêtre F-94276, France; Department of Neurosurgery (E.L.), Brigham & Women’s Hospital, Boston, Massachusetts 02115; Department of Internal Medicine (J.S.), University of Iowa, Iowa City, Iowa 52242; Department of Medicine (M.L.V.), University of Virginia, Charlottesville, Virginia 22904; Pituitary Research Unit (K.H.), Garvan Institute of Medical Research, Sydney NSW 2010, Australia; and Department of Internal Medicine (A.G.), University of Brescia, 25121 Brescia, Italy
Received November 6, 2008. Accepted January 30, 2009.
Address all correspondence and requests for reprints to: S. Melmed, M.D., Cedars-Sinai Research Institute, 8700 Beverly Boulevard, Room 2015, Los Angeles, California 90048.
This study was sponsored by the Pituitary Society and the European Neuroendocrine Association and was supported by unrestricted grants from Ipsen and Tercica, Inc. Editorial assistance was provided by ESP BioScience.
Disclosure Summary: A.C., D.C., E.L., J.S., and M.L.V. have nothing to declare. A.B. has consulted for Ipsen. M.M. has received research grants from Tercica and Ipsen and has consulted, received honoraria, and been a spokesperson for Tercica. A.B.G. has consulted for, served on advisory boards for, received honoraria from, and been a spokesperson for Ipsen and Novartis. D.K. has consulted for, served on advisory boards for, and received honoraria from Ipsen. P.C. has served on advisory boards for Novartis and has received honoraria from Novartis, Ipsen, and Pfizer. K.H. has consulted for Novartis and Ipsen. S.M. has consulted for Novartis and Ipsen and received a grant from Novartis. A.G. has consulted for Ipsen, Pfizer, and Italfarmaco and has received lecture fees from Novartis and Italfarmaco.
First Published Online February 10, 2009
Abbreviations: CI, Confidence interval; DA, dopamine agonist; DR, discretionary recommendations; GHRA, GH receptor antagonist; HQ, high quality; LQ, low quality; MQ, moderate quality; MRI, magnetic resonance imaging; OGTT, oral glucose tolerance test; OSA, obstructive sleep apnea; QoL, quality of life; SMR, standardized mortality ratio; SR, strong recommendations; SRL, somatostatin receptor ligand; VLQ, very low quality.
