From the Mary S. Easton Center for Alzheimer’s Disease Research, University of California, Los Angeles, Department of Neurology, Los Angeles, California (JMR, DWN, YZ, AN, GC, MFM, ST, HVV); Memory and Aging Center, Keck School of Medicine of University of Southern California, Los Angeles, California (JMR); Department of Biostatistics, University of Washington, Seattle, Washington (SM); Department of Pathology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California (DWN, ST, HVV); Semel Institute for Neuroscience and Human Behavior, Los Angeles, California (GC,VVB); Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois (SW, M-MM, EHB, DRG); Advocate Lutheran General Hospital, Park Ridge, Illinois (DRG); Department of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois (DRG); Department of Pathology, University of Michigan, Ann Arbor, Michigan (AOF-H); VA Ann Arbor Healthcare System, Geriatrics Research, Education, and Clinical Center, Ann Arbor, Michigan (RLA); and Department of Neurology, University of Michigan, Ann Arbor, Michigan (RLA).
Dr Ringman reports grants from National Institute on Aging (NIA) during the conduct of the study and grants from Biogen-Idec, grants from Eli-Lilly, and personal fees from InnoSense, LLC, outside the submitted work. Dr Zhou, Dr Albin, Dr Fisher-Hubbard, Dr Mendez, Dr Bigio, Ms Monsell, Dr Ng, Mr Nguyen, Dr Weintraub, and Mr Tung report grants from NIA during the conduct of the study. Dr Gitelman reports grants from Merck & Co. and Forum Pharmaceuticals and personal fees from Gerson Lehrman Group, O’Neill, McFadden & Willett, Neurometrika, Community Hospital of South Bend, Traveler’s Insurance Co, J Reckner, Bluespark Communication, Elsevier, and Silverado Senior Living outside the submitted work. Dr Coppola reports grants from NIA during the conduct of the study and grants from Tau Consortium, Takeda Pharmaceuticals, French Foundation, and National Institute of Health (NIH) outside the submitted work. Dr Vinters reports grants from NIA during the conduct of this study; his trust owns shares in biotechnology and pharma companies, from which he receives dividends; these holdings have no conflict with the work described. Dr Van Berlo and Dr Mesulam have no duality or conflicts of interest to declare.
This study was supported by funding received by the lead author, John M. Ringman, from NIH (U19AG032438, P50 AG-16570, P50 AG-005142, and 1UL1-RR033176). The National Alzheimer’s Coordinating Center (NACC) database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA-funded Alzheimer’s Disease Centers (ADCs): P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Steven Ferris, PhD), P30 AG013854 (PI M. Marsel Mesulam, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG016570 (PI David Teplow, PhD), P50 AG005131 (PI Douglas Galasko, MD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P50 AG005136 (PI Thomas Montine, MD, PhD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), and P50 AG005681 (PI John Morris, MD).
Send correspondence to: John M. Ringman, MD, MS, Keck School of Medicine of University of Southern California, Center for the Health Professionals, 1540 Alcazar Street, Suite 209F, Los Angeles, CA 90089-0080; E-mail: [email protected]
