Male Anorgasmia Treated with Oxytocin

IsHak, Waguih William MD, FAPA
Berman, Daniel S. MD
Peters, Anne MD

^*Cedars-Sinai Medical Center—Psychiatry, Los Angeles, CA, USA; ^†University of California at Los Angeles (UCLA)—Psychiatry, Los Angeles, CA, USA; ^‡Cedars-Sinai Medical Center—Cardiology, Los Angeles, CA, USA; ^§Endocrinology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA

Corresponding Author: Waguih William IsHak, MD, FAPA, Cedars-Sinai Medical Center—Psychiatry, 8730 Alden Dr, Thalians W-157, Los Angeles, CA 90048, USA. Tel: 310-423-3515; Fax: 310-423-3947; E-mail: [email protected]

Conflict of Interest: None declared.

The Journal of Sexual Medicine 5(4):p 1022-1024, April 2008.

Introduction

This is a case report on male anorgasmia that was successfully treated with oxytocin. Oxytocin is increased during arousal and peaks during orgasm. More recently, a study on humans published in Nature has shown its value in social bonding, increasing trust, and enhancing the sense of well-being.

Aim

To test the effectiveness of administering oxytocin in a case of treatment-resistant anorgasmia.

Methods

The patient underwent a biopsychosocial evaluation by a psychiatrist trained in sexual medicine and sex therapy for male orgasmic disorder, acquired type. Medical conditions, effect of substances, and psychological issues were ruled out. The patient was properly consented to using oxytocin as an off-label trial. Oxytocin was administered using a nasal spray intracoitally because of its ultra-short half-life.

Results

Oxytocin was effective in restoring ejaculation.

Conclusions

A case of treatment-resistant male anorgasmia was successfully treated with intracoital administration of intranasal oxytocin.