Transplant Renal Artery Stenosis In A Canine Model: Evaluation Of Hemodynamic Changes, Renal Function, And Captopril Renography

Sankari, Bashir R.
Stowe, Nicholas T.
Nally, Joseph V.
Gavin, James P.
Remzi, Feza H.
Novick, Andrew C.

From the Departments of Urology, Hypertension and Nephrology, The Cleveland Clinic Foundation, Cleveland, Ohio

^*Requests for reprints: Department of Urology, Cleveland Clinic Foundation, 1 Clinic Center Drive, Cleveland, OH 44195.

Accepted September 17, 1991.

Journal of Urology 147(3):p 723-726, March 1992. | DOI: 10.1016/S0022-5347(17)37366-4

ABSTRACT

The utility of captopril renography in the diagnosis of renal artery stenosis was examined in a canine model of renal autotransplantation with and without renal artery clipping. Autotransplantation of the left kidney to the right iliac fossa with contralateral nephrectomy was done in female mongrel dogs. One group served as controls (n = 6). A second group underwent constriction of the external diameter of the renal artery at the time of the operation to produce renal artery stenosis (n = 7). At two weeks postoperatively, glomerular filtration rate was significantly lower in the renal artery stenosis group (26.2 ± 3.4 ml./min. vs. 38.2 ± 3.2 ml./min., p <0.05), and deteriorated further after captopril administration (17.9 ± 2.7 ml./min. vs. 26.2 ± 3.4 ml./min., p <0.05). Despite the presence of hemodynamically significant renal artery stenosis, mean arterial pressure was not different between the two groups (134 ± 4 mm. Hg vs. 132 ± 6 mm. Hg, control vs. renal artery stenosis, p = NS). Captopril renography did not enable detection of renal artery stenosis in this autotransplant model.