Effects of Prazosin in Patients with Benign Prostatic Obstruction

Hedlund, H.
Andersson, K.-E.
Ek, A.

From the Departments of Urology and Clinical Pharmacology, University Hospital of Lund, Lund, Sweden

Accepted December 17, 1982.

Supported in part by grants from the Swedish Research Council, project No. 17X-04264.

Journal of Urology 130(2):p 275-278, August 1983. | DOI: 10.1016/S0022-5347(17)51106-4

ABSTRACT

Prazosin, a selective alpha-1-adrenoceptor blocker, was used in a double-blind crossover study in 20 men with benign prostatic obstruction. Maximum and average flow rates increased, and residual volume and obstructive symptoms were reduced. Voiding pressure parameters, bladder capacity and irritative symptoms did not change significantly. No side effects were noted. We conclude that prazosin seems to be an effective therapeutic alternative in patients with benign prostatic obstruction.