A comprehensive genetic map of the human genome based on 5,264 microsatellites

Dib, Colette
Faure, Sabine
Fizames, Cecile
Samson, Delphine
Drouot, Nathalie
Vignal, Alain
Millasseau, Philippe
Marc, Sophie
Hazan, Jamile
Seboun, Eric
Lathrop, Mark
Gyapay, Gabor
Morissette, Jean
Weissenbach, Jean

(Dib, Faure, Fizames, Samson, Drouot, Vignal, Millasseau, Marc, Hazan, Seboun, Gyapay, Morissette, Weissenbach) Genethon and CNRS URA 1922, 1 rue de l'Internationale, 91000 Evry, France.
(Lathrop) INSERM U358, Hopital Saint-Louis, Paris, France.
(Morissette) Centre de Recherche du Centre Hospitalier de l'Universite Laval, Quebec G1V 4G2, Canada.
(Weissenbach) To whom correspondence should be addressed.

Nature 380(6570):p 152-154, March 14, 1996.

THE great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps *RF 1-6*, which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites . We report here the last version of the Genethon human linkage map . This map consists of 5,264 short tandem (AC/TG) sub n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.