Osteoimmunology: Bone versus immune system

Arron, Joseph R.
Choi, Yongwon

Joseph R. Arron is in the Tri-Institutional MD-PhD Program and Yongwon Choi is at the Howard Hughes Medical Institute, Laboratory of Immunology, The Rockefeller University, New York, New York 10021, USA.
e-mails: [email protected]; [email protected]

Nature 408(6812):p 535-536, November 30, 2000.

A molecule on activated T cells triggers bone loss by switching on bone-resorbing cells. Fortunately, it seems that this mechanism is kept in check by another molecule, secreted by the T cells.