Somatic cell nuclear transfer

Wilmut, I.
Beaujean, N.
de Sousa, P. A.
Dinnyes, A.
King, T. J.
Paterson, L. A.
Wells, D. N.
Young, L. E.

* Roslin Institute, Roslin, Midlothian EH25 9PS, UK
‡ AgResearch Ltd, PB3123, Hamilton, New Zealand

† Present addresses: Research Group for Animal Breeding, Hungarian Academy of Sciences & Szent István University, Hungary (A.D.); and School of Human Development, Division of Reproductive Medicine, Queens Medical Centre, Nottingham NG7 2UH, UK (L.E.Y.).

doi:10.1038/nature01079.

Correspondence and requests for materials should be addressed to I.W.

(e-mail: [email protected]).

Nature 419(6709):p 583-586, October 10, 2002.

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.