CELL BIOLOGY: Chromosome territories

Meaburn, Karen J.
Misteli, Tom

Karen J. Meaburn and Tom Misteli are at the National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. e-mail: [email protected]

Nature 445(7126):p 379-381, January 25, 2007.

The natural habitat of eukaryotic genomes is the cell nucleus, where each chromosome is confined to a discrete region, referred to as a chromosome territory. This spatial organization is emerging as a crucial aspect of gene regulation and genome stability in health and disease.