RNA INTERFERENCE: Generic block on angiogenesis

Kalluri, Raghu
Kanasaki, Keizo

Raghu Kalluri and Keizo Kanasaki are in the Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. e-mail: [email protected]

Nature 452(7187):p 545, April 3, 2008. | DOI: 10.1038/452543a

A virtue of using small interfering RNAs as therapeutics is their exquisite specificity. But when it comes to inhibiting blood-vessel growth, it seems that they can act generically without even entering a cell.